PandemieGrippaleV1, France, Analysis, bibRecord, 000455

Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis

Identifieur interne : 000455 ( France/Analysis ); précédent : 000454; suivant : 000456

Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis

Auteurs : O. Launay [France] ; P. Y. Boelle [France] ; A. Krivine [France] ; D. Grenet [France] ; V. Boussaud [France] ; N. Remus [France] ; H. Corvol [France] ; F. Chedevergne [France] ; D. Hubert [France] ; I. Sermet-Gaudelus [France]

Source :

Vaccine [ 0264-410X ] ; 2014.

RBID : Pascal:14-0190727

Descripteurs français

Pascal (Inist)
- Virus grippal A, Immunité humorale, Réponse immune, Vaccin, Adjuvant immunologique, Malnutrition, Grippe A, Mucoviscidose.
Wicri :
- topic : Vaccin, Malnutrition.

English descriptors

KwdEn :
- Cystic fibrosis, Humoral immunity, Immune response, Immunological adjuvant, Influenza A, Influenza A virus, Malnutrition, Vaccine.

Abstract

Influenza vaccination is recommended in cystic fibrosis patients. The objective of this study was to assess the immunogenicity of vaccination against 2009 pandemic A/H1N1 influenza and to study the factors associated with the immune response in patients with cystic fibrosis. 122 patients with cystic fibrosis were enrolled in a prospective study and received 1 dose of 2009/H1N1v adjuvanted vaccine, or for children <2 years and lung-transplanted patients, two doses of non-adjuvanted 2009/H1N1v vaccine administered 21 days apart. Hemagglutination inhibition antibodies were assessed before and 21 days after vaccination and at least 6 months after vaccination. After vaccination, 85% of the patients had an influenza antibody titer ≥1:40 and 69% seroconverted. 13% of the transplanted patients seroconverted compared with 72% of the non-transplanted patients. In this latter group, non-adjuvanted vaccine and low body mass index were independently associated with lower response to vaccination. 86% of the non-transplanted patients with normal BMI and receiving adjuvanted vaccine seroconverted. Persistence of seroprotection 10 months after vaccination was found in 50% of the patients. In patients with cystic fibrosis, malnutrition and receipt of non-adjuvanted vaccine were associated with lower immune response to pandemic influenza vaccination. Our data also suggest a potential defect in the immune response to influenza vaccination of patients with cystic fibrosis and raise the question of whether a different immunization strategy is needed.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000061
to stream PascalFrancis, to step Curation: 001D58
to stream PascalFrancis, to step Checkpoint: 000102
to stream Main, to step Merge: 001103
to stream Main, to step Curation: 001093
to stream Main, to step Exploration: 001093
to stream France, to step Extraction: 000455

Links to Exploration step

Pascal:14-0190727

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis</title>
<author><name sortKey="Launay, O" sort="Launay, O" uniqKey="Launay O" first="O." last="Launay">O. Launay</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, CIC 1417</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Université Paris Descartes, Paris Sorbonne Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, CIC Cochin-Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boelle, P Y" sort="Boelle, P Y" uniqKey="Boelle P" first="P. Y." last="Boelle">P. Y. Boelle</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM, U707</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krivine, A" sort="Krivine, A" uniqKey="Krivine A" first="A." last="Krivine">A. Krivine</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, Service de Virologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grenet, D" sort="Grenet, D" uniqKey="Grenet D" first="D." last="Grenet">D. Grenet</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Hôpital Foch, Service de Pneumologie</s1>
<s2>Suresnes</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Suresnes</wicri:noRegion>
<wicri:noRegion>Service de Pneumologie</wicri:noRegion>
<wicri:noRegion>Suresnes</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boussaud, V" sort="Boussaud, V" uniqKey="Boussaud V" first="V." last="Boussaud">V. Boussaud</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Chirurgie Thoracique</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Remus, N" sort="Remus, N" uniqKey="Remus N" first="N." last="Remus">N. Remus</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre Hospitalier Intercommunal de Créteil, Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corvol, H" sort="Corvol, H" uniqKey="Corvol H" first="H." last="Corvol">H. Corvol</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Trousseau, Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chedevergne, F" sort="Chedevergne, F" uniqKey="Chedevergne F" first="F." last="Chedevergne">F. Chedevergne</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pediatrique et Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hubert, D" sort="Hubert, D" uniqKey="Hubert D" first="D." last="Hubert">D. Hubert</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, Service de Pneumologie, Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sermet Gaudelus, I" sort="Sermet Gaudelus, I" uniqKey="Sermet Gaudelus I" first="I." last="Sermet-Gaudelus">I. Sermet-Gaudelus</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Université Paris Descartes, Paris Sorbonne Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pediatrique et Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>INSERM U 1151</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0190727</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 14-0190727 INIST</idno>
<idno type="RBID">Pascal:14-0190727</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000061</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001D58</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000102</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000102</idno>
<idno type="wicri:doubleKey">0264-410X:2014:Launay O:factors:associated:with</idno>
<idno type="wicri:Area/Main/Merge">001103</idno>
<idno type="wicri:Area/Main/Curation">001093</idno>
<idno type="wicri:Area/Main/Exploration">001093</idno>
<idno type="wicri:Area/France/Extraction">000455</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis</title>
<author><name sortKey="Launay, O" sort="Launay, O" uniqKey="Launay O" first="O." last="Launay">O. Launay</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, CIC 1417</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Université Paris Descartes, Paris Sorbonne Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, CIC Cochin-Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boelle, P Y" sort="Boelle, P Y" uniqKey="Boelle P" first="P. Y." last="Boelle">P. Y. Boelle</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM, U707</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krivine, A" sort="Krivine, A" uniqKey="Krivine A" first="A." last="Krivine">A. Krivine</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, Service de Virologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grenet, D" sort="Grenet, D" uniqKey="Grenet D" first="D." last="Grenet">D. Grenet</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Hôpital Foch, Service de Pneumologie</s1>
<s2>Suresnes</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Suresnes</wicri:noRegion>
<wicri:noRegion>Service de Pneumologie</wicri:noRegion>
<wicri:noRegion>Suresnes</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boussaud, V" sort="Boussaud, V" uniqKey="Boussaud V" first="V." last="Boussaud">V. Boussaud</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Chirurgie Thoracique</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Remus, N" sort="Remus, N" uniqKey="Remus N" first="N." last="Remus">N. Remus</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre Hospitalier Intercommunal de Créteil, Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corvol, H" sort="Corvol, H" uniqKey="Corvol H" first="H." last="Corvol">H. Corvol</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Trousseau, Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chedevergne, F" sort="Chedevergne, F" uniqKey="Chedevergne F" first="F." last="Chedevergne">F. Chedevergne</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pediatrique et Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hubert, D" sort="Hubert, D" uniqKey="Hubert D" first="D." last="Hubert">D. Hubert</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Cochin, Service de Pneumologie, Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sermet Gaudelus, I" sort="Sermet Gaudelus, I" uniqKey="Sermet Gaudelus I" first="I." last="Sermet-Gaudelus">I. Sermet-Gaudelus</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Université Paris Descartes, Paris Sorbonne Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pediatrique et Centre de Ressources et de Compétences en Mucoviscidose</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>INSERM U 1151</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cystic fibrosis</term>
<term>Humoral immunity</term>
<term>Immune response</term>
<term>Immunological adjuvant</term>
<term>Influenza A</term>
<term>Influenza A virus</term>
<term>Malnutrition</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus grippal A</term>
<term>Immunité humorale</term>
<term>Réponse immune</term>
<term>Vaccin</term>
<term>Adjuvant immunologique</term>
<term>Malnutrition</term>
<term>Grippe A</term>
<term>Mucoviscidose</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
<term>Malnutrition</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Influenza vaccination is recommended in cystic fibrosis patients. The objective of this study was to assess the immunogenicity of vaccination against 2009 pandemic A/H1N1 influenza and to study the factors associated with the immune response in patients with cystic fibrosis. 122 patients with cystic fibrosis were enrolled in a prospective study and received 1 dose of 2009/H1N1v adjuvanted vaccine, or for children <2 years and lung-transplanted patients, two doses of non-adjuvanted 2009/H1N1v vaccine administered 21 days apart. Hemagglutination inhibition antibodies were assessed before and 21 days after vaccination and at least 6 months after vaccination. After vaccination, 85% of the patients had an influenza antibody titer ≥1:40 and 69% seroconverted. 13% of the transplanted patients seroconverted compared with 72% of the non-transplanted patients. In this latter group, non-adjuvanted vaccine and low body mass index were independently associated with lower response to vaccination. 86% of the non-transplanted patients with normal BMI and receiving adjuvanted vaccine seroconverted. Persistence of seroprotection 10 months after vaccination was found in 50% of the patients. In patients with cystic fibrosis, malnutrition and receipt of non-adjuvanted vaccine were associated with lower immune response to pandemic influenza vaccination. Our data also suggest a potential defect in the immune response to influenza vaccination of patients with cystic fibrosis and raise the question of whether a different immunization strategy is needed.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Créteil</li>
<li>Paris</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Launay, O" sort="Launay, O" uniqKey="Launay O" first="O." last="Launay">O. Launay</name>
</region>
<name sortKey="Boelle, P Y" sort="Boelle, P Y" uniqKey="Boelle P" first="P. Y." last="Boelle">P. Y. Boelle</name>
<name sortKey="Boussaud, V" sort="Boussaud, V" uniqKey="Boussaud V" first="V." last="Boussaud">V. Boussaud</name>
<name sortKey="Chedevergne, F" sort="Chedevergne, F" uniqKey="Chedevergne F" first="F." last="Chedevergne">F. Chedevergne</name>
<name sortKey="Corvol, H" sort="Corvol, H" uniqKey="Corvol H" first="H." last="Corvol">H. Corvol</name>
<name sortKey="Grenet, D" sort="Grenet, D" uniqKey="Grenet D" first="D." last="Grenet">D. Grenet</name>
<name sortKey="Hubert, D" sort="Hubert, D" uniqKey="Hubert D" first="D." last="Hubert">D. Hubert</name>
<name sortKey="Krivine, A" sort="Krivine, A" uniqKey="Krivine A" first="A." last="Krivine">A. Krivine</name>
<name sortKey="Launay, O" sort="Launay, O" uniqKey="Launay O" first="O." last="Launay">O. Launay</name>
<name sortKey="Launay, O" sort="Launay, O" uniqKey="Launay O" first="O." last="Launay">O. Launay</name>
<name sortKey="Remus, N" sort="Remus, N" uniqKey="Remus N" first="N." last="Remus">N. Remus</name>
<name sortKey="Sermet Gaudelus, I" sort="Sermet Gaudelus, I" uniqKey="Sermet Gaudelus I" first="I." last="Sermet-Gaudelus">I. Sermet-Gaudelus</name>
<name sortKey="Sermet Gaudelus, I" sort="Sermet Gaudelus, I" uniqKey="Sermet Gaudelus I" first="I." last="Sermet-Gaudelus">I. Sermet-Gaudelus</name>
<name sortKey="Sermet Gaudelus, I" sort="Sermet Gaudelus, I" uniqKey="Sermet Gaudelus I" first="I." last="Sermet-Gaudelus">I. Sermet-Gaudelus</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000455 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000455 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:14-0190727
   |texte=   Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis
}}

This area was generated with Dilib version V0.6.34.
Data generation: Wed Jun 10 11:04:28 2020. Site generation: Sun Mar 28 09:10:28 2021

	Serveur d'exploration sur les pandémies grippales
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les pandémies grippales

Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis

Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri